摘要 |
The invention relates to products and methods for modulating amyloid precursor protein (APP) translation and/or amyloid ß(Aß) secretion. The methods of the invention are useful to prevent and treat APP translation and/or Aß secretion-associated neurological disorders such as Alzheimer's disease, Down's syndrome, cerebrovascular amyloidosis, Hereditary Amyloidosis with Cerebral Hemorrhage of the Dutch Type, vascular dementia, and inclusion body myositis.
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申请人 |
THE GENERAL HOSPITAL CORPORATION;THE BRIGHAM AND WOMEN'S HOSPITAL, INC.;ROGERS, JACK;PAYTON, SANDRA;GULLANS, STEVE;RANDALL, JEFF;SARANG, SATINDER |
发明人 |
ROGERS, JACK;PAYTON, SANDRA;GULLANS, STEVE;RANDALL, JEFF;SARANG, SATINDER |