| 发明名称 |
Amino ceramide-like compounds and therapeutic methods of use |
| 摘要 |
The present invention provides amino ceramide-like compounds which inhibit glucosyl ceramide (GlyCer) formation by inhibiting the enzyme GlyCer synthase, thereby lowering the level of glycosphingolipids. The compounds of the present invention have improved GlcCer synthase inhibition activity and are therefore useful in therapeutic methods for treating various conditions and diseases associated with altered glycosphingolipid levels.
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| 申请公布号 |
US2005049235(A1) |
申请公布日期 |
2005.03.03 |
| 申请号 |
US20040839497 |
申请日期 |
2004.05.05 |
| 申请人 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN |
发明人 |
SHAYMAN JAMES A.;RADIN NORMAN S. |
| 分类号 |
A61K31/397;A61K31/40;A61K31/4025;A61K31/445;A61K31/451;A61K31/5377;C07D295/13;C07D317/54;C07D319/18;C07D321/10;C07D413/02;(IPC1-7):C07D265/30;A61K31/537 |
主分类号 |
A61K31/397 |
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