Use of arginine in the preparation of a medicament for the prevention and treatment of the side effects associated with the extravasation of drugs administered by intravenous routes

摘要

Arginine is used in the preparation of a medicament for the prevention and treatment of the side effects associated with the extravasation of drugs administered by intravenous route. Arginine may also be used with an antineoplastic agent in the preparation of an antitumor medicament for intravenous administration for preventing and treating the side effects associated with the extravasation of the antineoplastic agent. Also disclosed is a intravenous formulation comprising arginine and an antineoplastic agent selected from doxorubicin, epirubicin, idarubicin, daunorubicin, alkylcyclin (4-demethoxy-3'-deamino-3'-aziridinyl-4'-mehtylsulfonyl-daunorubicin), paclitaxel, docetaxel, Sugen SU-5416 and Sugen SU-6668.