| 摘要 |
FIELD: metallorganic compounds, chemical technology, medicine. ^ SUBSTANCE: invention relates to derivatives of platinum tetrachloride and to a method for their preparing. Compounds of the formula: PtCl4 x 2 Li have been prepared wherein Li represents N,N-dithanolnicotinamide or N,N-diethanolisonicotinamide, N-(trimethylolmethane)-nicotinamide, or N-ethanolnicotinamide, or N-ethanolisonicotinamide. Invention proposes a method for preparing indicated compounds that involves treatment of alkanolamines with pyridine carboxylic acid alkyl ester followed by separation of formed pyridine carboxylic acid alkanolamide, its treatment with potassium or sodium hexachloroplatinate and isolation of the end product. Prepared compounds can be used in medicinal practice instead cisplatin as effective low-toxic antimetastatic medicinal agents. ^ EFFECT: improved preparing method, valuable medicinal properties of compounds. ^ 2 cl, 6 ex |
