5'-AND 3'-CAPPED APTAMERS AND USES THEREFOR

摘要

The invention provides compositions and methods for the treating disease using aptamers having 5'-5'and 3'-3' inverted nucleotide capped ends. In particular, the invention provides 5'-5' and 3'-3' capped and-VEGF aptamers of the treatment of neovascularization-related diseases and disorders including age-related macular degeneration.