发明名称 |
PROCESS FOR PRODUCING DRUG ULTRAMICROPARTICLE AND APPARATUS THEREFOR |
摘要 |
<p>Drug fine particles of submicron size excelling in long-term dispersibility. In particular, there is provided a process for producing drug ultramicroparticles of 10 to 1000 nm average diameter, comprising (1) dissolving a drug in at least one type of good solvent or good mixed solvent to thereby obtain a drug-containing solution; (2) mixing the drug-containing solution with a, to the drug, poor solvent or poor mixed solvent that is miscible with the drug-containing solution prepared with the good solvent or good mixed solvent; and (3) without any pretreatment step for adjusting the average particle diameter of the drug to 100 mum or less, directly emulsifying the resultant mixed solution at given treating pressure by the use of high-pressure homogenizer. There is further provided an apparatus therefor.</p> |
申请公布号 |
WO2005013938(A1) |
申请公布日期 |
2005.02.17 |
申请号 |
WO2004JP11518 |
申请日期 |
2004.08.04 |
申请人 |
EISAI CO., LTD.;KATO, AKIRA;YAMAGUCHI, TAKEHIRO;NOMURA, TERUKO;ONAI, KATSUMI |
发明人 |
KATO, AKIRA;YAMAGUCHI, TAKEHIRO;NOMURA, TERUKO;ONAI, KATSUMI |
分类号 |
A61K9/14;A61K9/16;A61K9/51;A61K47/18;A61K47/34;A61K47/44;A61P1/00;A61P3/02;A61P3/06;A61P3/10;A61P5/00;A61P9/10;A61P9/12;A61P19/10;A61P25/04;A61P25/08;A61P25/20;A61P29/00;A61P31/04;A61P35/00;A61P37/08;B01F5/10;B01F17/14;B01F17/42;B01F17/52;(IPC1-7):A61K9/16 |
主分类号 |
A61K9/14 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|