发明名称 |
TREATMENT OF INFLAMED JOINTS |
摘要 |
The present invention relates to trans-capsularly administering into a diseased joint a high specificity antagonist selected from the group consisting of: i) an inhibitor of a pro-inflammatory interleukin; ii) an inhibitor of TNF-alpha synthesis; iii) an inhibitor of membrane-bound TNF- alpha; iv) an inhibitor of a natural receptor of TNF-alpha; v) an inhibitor of NO synthase, vi) an inhibitor of PLA2 enzyme; vii) an anti-proliferative agent; viii) an anti-oxidant; ix) an apoptosis inhibitor selected from the group consisting of EPO mimetic peptides, EPO mimetibodies, IGF-1, IFG-II, a nd caspase inhibitors, and x) an inhibitor of MMPs; and xi) an inhibitor of p38 kinase. Conpounds include Rapamycin, NG-Monomethyl-L-Arginine, Infliximab, L - NIL, IGF-1, IGF-2.
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申请公布号 |
CA2534327(A1) |
申请公布日期 |
2005.02.10 |
申请号 |
CA20042534327 |
申请日期 |
2004.07.30 |
申请人 |
DEPUY SPINE, INC. |
发明人 |
SIEKIERKA, JOHN;KADIYALA, SUDHAKAR;SMITH, CATHERINE;PLOUHAR, PAMELA L.;GEESIN, JEFF;GRACE, MELISSA;SERHAN, HASSAN;REYNOLDS, MARTIN A.;DIMAURO, THOMAS M.;COLLINS, GREGORY;BROWN, LAURA J.;BRUDER, SCOTT;ATTAWIA, MOHAMED;URBAHNS, DAVID |
分类号 |
A61K31/436;A61K31/198;A61K38/18;A61K38/30;A61K39/395;A61P19/02 |
主分类号 |
A61K31/436 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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