CROSSLINKED COMPOSITIONS COMPRISING COLLAGEN AND DEMINERALIZED BONE MATRIX
摘要
<p>A composition comprising a collagen protein and demineralized bone matrix is described wherein the composition is chemically cross-linked with a carbodiimide such as N-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride (EDC). The crosslinking reaction can be conducted in the presence of N-hydroxysuccinimide (NHS). The collagen can be in a porous matrix or scaffolding. The DBM can be in the form of particles dispersed in the collagen. A method of making the composition is also described wherein a collagen slurry is cast into the desired shape, freeze dried to form a porous scaffolding and infiltrated with a solution comprising the cross-linking agent. The composition can be used as an implant for tissue (e.g., soft tissue or bone) engineering.</p>
申请公布号
WO2005011764(A1)
申请公布日期
2005.02.10
申请号
WO2004US23557
申请日期
2004.07.22
申请人
SDGI HOLDINGS, INC.;MCKAY, WILLIAM, F.;TORRIANNI, MARK, W.;EVERAERTS, F.J.L.;DRAPEAU, SUSAN, J.
发明人
MCKAY, WILLIAM, F.;TORRIANNI, MARK, W.;EVERAERTS, F.J.L.;DRAPEAU, SUSAN, J.