BSEP POLYPEPTIDE VARIANTS AND USES THEREOF

摘要

The invention provides isolated nucleic acids encoding BSEP polypeptide variants, wherein the nucleic acids comprise a segment of nucleotides at a position which corresponds to the junction of Exon I and Exon II of a human BSEP polypeptide nucleotide sequence, and the polypeptide encoded by these nucleic acids. The invention also provides vectors, host cells, and transgenic animals comprising a nucleic acid encoding a BSEP polypeptide variant. The invention provides antibodies that specifically bind to the BSEP polypeptide variants of the invention. The invention also provides methods of identifying compounds that are substrates and/or modulators of the BSEP polypeptide variants of the invention. Finally, the invention provides methods of inhibiting the expression of a BSEP polypeptide variant of the invention.