发明名称 |
Human hypoxanthine-(guanine) phosphoribosyl transferase-2 |
摘要 |
A human HPRT-2 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for the treatment of nephrolithiasis, anemia, precocious gout, kidney stones, Lesch-Nyhan syndrome, renal failure and uricaciduria. Antagonists against such polypeptides and their use as a therapeutic to treat disorders associated with excessive purine synthesis are also disclosed. Diagnostic assays for identifying mutations in nucleic acid sequences encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
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申请公布号 |
US6849436(B2) |
申请公布日期 |
2005.02.01 |
申请号 |
US20010902705 |
申请日期 |
2001.07.12 |
申请人 |
HUMAN GENOME SCIENCES, INC. |
发明人 |
BEDNARIK DANIEL P.;ROSEN CRAIG A.;ADAMS MARK D. |
分类号 |
C12N15/09;A61K38/00;A61K39/395;A61K45/00;A61P7/00;A61P9/00;A61P9/12;A61P19/06;A61P25/00;C07K16/18;C07K16/40;C12N1/21;C12N5/10;C12N9/10;C12N9/12;C12P21/08;C12R1/19;C12R1/91;(IPC1-7):C12N9/10;C12N5/00;C12P21/06;C07H21/04;C07K17/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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