发明名称 STABLE NON-DIHYDRATE AZITHROMYCIN ORAL SUSPENSIONS
摘要 This invention relates to a powder for oral suspension, and an oral suspension made there from, which comprises non-dehydrate azithromycin and an azithromycin conversion stabilizing excipient, wherein said excipient reduces the conversion of the form of azithromycin, when placed in suspension, to another form of azithromycin. This invention further relates to a method for reducing the conversion of a form of non-dehydrate azithromycin, in an oral suspension, by adding a surface tension reducing excipient that reduces the surface tension of the aqueous vehicle. Furthermore, this invention relates to a method for reducing the conversion of a non-dehydrate azithromycin, in an unflavored oral suspension, by raising the viscosity of the oral suspension, and in a flavored oral suspension by lowering the viscosity of the oral suspension.
申请公布号 CA2464831(A1) 申请公布日期 2005.01.15
申请号 CA20042464831 申请日期 2004.04.21
申请人 PFIZER PRODUCTS INC. 发明人 COLLIER, STEVEN WILLIAM;JOHNSON, BARBARA ALICE;CURATOLO, WILLIAM JOHN;MURPHY, BRENDAN JOHN
分类号 A61K9/10;A61K9/00;A61K31/7042;A61K31/7048;A61K47/04;A61K47/26;A61K47/36;A61K47/38;A61K47/46;(IPC1-7):A61K31/705;A61K47/30 主分类号 A61K9/10
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