发明名称 |
CRYSTALLINE AND PURE MODAFINIL, AND PROCESS OF PREPARING THE SAME |
摘要 |
The present invention provides an improved process for preparing modafinil, whereby it may be isolated in high purity by a single crystallization. The process produces modafinil free of sulphone products of over-oxidation and other byproducts. The invention further provides new crystalline Forms II-VI of modafinil and processes for preparing them. Each of the new forms is differentiated by a unique powder X-ray diffraction pattern. The invention further provides pharmaceutical compositions containing novel modafinil Forms II-IV and VI. |
申请公布号 |
PL365613(A1) |
申请公布日期 |
2005.01.10 |
申请号 |
PL20010365613 |
申请日期 |
2001.07.27 |
申请人 |
TEVA PHARMACEUTICAL INDUSTRIES LTD. |
发明人 |
SINGER CLAUDE;GERSHON NEOMI;CEAUSU ARINA;LIEBERMAN ANITA;ARONHIME JUDITH |
分类号 |
A61K;A61K31/165;C07C;C07C315/02;C07C315/06;C07C317/44;C30B7/00 |
主分类号 |
A61K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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