| 摘要 |
It is intended to detect and screen proliferative insulin-producing cells and to differentiate and proliferate the insulin-producing cells, precursor cells thereof or cells analogous thereto. Genes expressed specifically in the pancreas of a PHHI patient, which are seemingly spontaneous proliferation models of pancreatic beta cells, are detected and, by searching for on a base sequence database, three novel genes are found out. Using these genes, gene products thereof or gene sequences thereof, insulin-producing cells under proliferation can be detected by, for example, Northern analysis or RT-PCR. By transferring these genes into appropriate cells by genetic engineering techniques, moreover, these cells can be differentiated into insulin-producing cells.
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