发明名称 ORALLY BIOAVAILABLE LOW MOLECULAR WEIGHT METALLOPORPHYRINS AS ANTIOXIDANTS
摘要 The invention relates to compounds which are orally bioavailable water solub le metalloporphyrins. These compounds, e.g. represented by Structural Formula (I): wherein R1 and R2 are each independently lower alkyl, cycloalkyl, halog en substituted alkyl or substituted or unsubstituted phenyl groups, are synthet ic catalytic scavengers of reactive oxygen chemical species. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of use of these compounds for preventing or arresting free radical associated diseases or conditions.
申请公布号 CA2528347(A1) 申请公布日期 2005.01.06
申请号 CA20042528347 申请日期 2004.06.03
申请人 EUKARION, INC. 发明人 MEUNIER, BERNARD;COSLEDAN, FREDERIC
分类号 C07D487/22;A61K31/409;A61K31/555;A61P25/00;A61P39/00 主分类号 C07D487/22
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