| 摘要 |
The present invention is directed to the oncolytic microorganisms expressing Heat Shock Protein, compositions or pharmaceutical compositions containing them, and to methods of kilking local and metastatic tumors using them. The microorganisms refer to viruses and bacteria, which can grow selectively within tumor cells in order to lyse tumor cells. Upon the microorganisms or compositions according to the present invention is administrated to a tumor patient, the oncolytic microorganisms lye tumor cells and the heat shock proteins expressed by the oncolytic microorganisms or administered simultaneously with the oncolytic microorganisms adhere to tumor antigen released by the lysing tumor cells, and bind to antigen-presenting cells so as to induce specific immune response against tumor cells, then to kill metastatic tumors. |
