| 摘要 |
FIELD: organic chemistry, medicine, pharmacy. ^ SUBSTANCE: invention relates to new compounds of the formula (I): ^ wherein Ar1 means pyrazole that can be substituted with one or some groups R1, R2 or R3; Ar2 means naphthyl, tetrahydronaphthyl each of that is substituted optionally 0-1 with groups R2; X means (C5-C8)-cycloalkenyl, phenyl optionally substituted with hydroxy-group or (C1-C4)-alkoxy-group, furan, pyridinonyl, pyrazolyl, pyridinyl optionally substituted with hydroxy-group or (C1-C4)-alkoxy-group, piperidinyl; Y means a bond or saturated branched or unbranched (C1-C4)-carbon chain wherein one methylene group is optionally substituted for NH; or Y is substituted optionally and independently with oxo-group; Z means morpholine, o-group, pyridinyl, furanyl, tetrahydrofuranyl, thiomorpholinyl, pentamethylene sulfide, pentamethylene sulfone, secondary or tertiary amine wherein nitrogen atom of amino-group is bond covalently with the following groups taken among (C1-C3)-alkyl and (C1-C5)-alkoxyalkyl; R1 means (C3-C10)-alkyl that is halogenated optionally, partially or completely; R2 means branched or unbranched (C1-C6)-alkyl that is halogenated partially or completely, halogen atom; R3 means phenyl, pyrimidinyl, pyrazolyl that are substituted with a single branched or unbranched (C1-C6)-alkyl, and pyridinyl optionally substituted with (C1-C3)-alkoxy-group or amino-group; W means oxygen atom (O), and its pharmaceutically acceptable salts. Compounds of the formula (I) inhibit producing cytokines that allows their applying in pharmaceutical composition for treatment of cytokine-mediated disease. ^ EFFECT: valuable medicinal properties of compounds and composition. ^ 13 cl, 1 tbl, 17 sch, 38 ex
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