NON-STEROIDAL INFALMMATION INHIBITORS

摘要

A compound of formula (I) wherein: n represents an integer 0, 1 or 2; X represents, O, S, NR<6a>, or CHR<6b>; R<1> represents hydrogen, halogen such as F, Cl or Br, NO2, hydroxy, cyano, -OC1-6 alkoxy such as methoxy, C1-6 alkyl such as methyl, NR<8>R<9> such as NH2, NR<8>COR<9> such as -NHCHO or -NHCOCH3, COOR<7> or CONR<8>R<9>; R<2> represents hydrogen, halogen such as F, Cl, Br, NO2, hydroxy, cyano, -OC1-6 alkoxy such as methoxy, C1-6 alkyl such as methyl, NR<8>R<9> such as NH2, NR<8>COR<9> such as -NHCHO or -NHCOCH3, COOR<7> or CONR<8>R<9>; R<3> represents hydrogen, halogen such as F, Cl, Br, NO2, hydroxy, cyano, -OC1-6 alkoxy such as methoxy, C1-6 alkyl such as methyl, NR<8>R<9> such as NH2, NR<8>COR<9> such as -NHCHO or -NHCOCH3, COOR<7>, CONR<8>R<9>; R<4> represents hydrogen, halogen such as F, Cl, Br, NO2, hydroxy, cyano, -OC1-6 alkoxy such as methoxy, C1-6 alkyl such as methyl, NR<8>R<9> such as NH2, NR<8>COR<9> such as -NHCHO or -NHCOCH3, COOR<7> or CONR<8>R<9>; R<5> represents H, C1-6 alkyl, or C1-6 alkenyl; R<6a> represents hydrogen, C1-6 alkyl, CO2C1-3 alkyl, COC1-3 alkyl or SO2C1-3 alkyl; R<6b> represents hydrogen, or C1-6 alkyl; R<7> represents hydrogen, C1-6 alkyl, C1-3 alkyleneSiC1-3 alkyl such as -CH2CH2Si(CH3)3; R<8> and R<9> independently represent hydrogen or C1-6 alkyl; including pharmaceutically acceptable esters, amides and carbamates thereof, salts thereof, solvates thereof, and solvates of such pharmaceutically acceptable esters, amides, carbamates and salts.