发明名称 |
Gene related to migraine in man |
摘要 |
Genes for familial hemeplegic migraine (FHM), episodic ataxia type-2 (EA-2), common forms of migraine, and other episodic neurological disorders, such as epilepsy, have been mapped to chromosome 19p13. A brain-specific P/Q type calcium channel subunit gene, covering 300 kb with 47 exons is provided. The exons and their surroundings reveal polymorphic variations and deleterious mutations that are linked to various types of cation channel dysfunctions causing episodic neurological disorders in man or animals.
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申请公布号 |
US6825332(B1) |
申请公布日期 |
2004.11.30 |
申请号 |
US19990269446 |
申请日期 |
1999.03.26 |
申请人 |
RIJKSUNIVERSITEIT TEL LEIDEN |
发明人 |
FRANTS RUNE ROBERT ISAK ERIK;FERRARI MICHEL DOMINIQUE;TERWINDT GISELA MARIE;OPHOFF ROEL ANDRE |
分类号 |
A01K67/027;C07K14/435;C07K14/705;C07K16/18;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/00;C12N15/09;C12N15/12;C12Q1/02;C12Q1/68;G01N33/68;(IPC1-7):C07H21/04;C07H21/02 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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