| 摘要 |
The use of fatty acid analogues of the formula (I), its salt or complex for the treatment and/or prevention of proliferative skin disorders, specifically for the inhibition of proliferation and/or differentiation of keratinocytes is disclosed: R1 ? [Xi ? CH2]n ? COOR2 (I) wherein R1 is: a C1-C24 alkene with one or more double bonds and/or with one or more triple bonds, and/or a C1-C24 alkyne, and/or a C1-C24 alkyl, or a C1-C24 alkyl substituted in one or several positions with one or more compounds selected from the group comprising fluoride, chloride, hydroxy, C1-C4 alkoxy, C1-C4 alkylthio, C2-C5 acyloxy or C1-C4 alkyl, and wherein R2 represents hydrogen or C1-C4 alkyl, and wherein n is an integer from 1 to 12, and wherein i is an odd number and indicates the position relative to COOR2, and wherein Xi independent of each other are selected from the group comprising O, S, SO, SO2, Se and CH2, and with the proviso that at least one of the Xi is not CH2, and with the proviso that if R1 is an alkyne or alkene, then the carbon-carbon triple bond or double bond is positioned between the ( w-1) carbon and the ( w-2) carbon, or between the ( w-2) carbon and the ( w-3) carbon, or between the ( w-3) carbon and the ( w-4) carbon.
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