| 摘要 |
A pharmaceutical composition comprises a sulfonamide compound, a sulfonate compound or a salt thereof and a compound selected from irinotecan hydrochloride trihydrate, mitomycin C, 5-fluroouracil, cisplatin, gemcitabine hydrochloride, doxorubicin, taxol or salt thereofwhich. The sulfonamide compound, a sulfonate compound is represented by formula (I) wherein: Ring A represents a monocyclic or bicyclic aromatic ring which may be substituted, Ring B represents a six-membered unsaturated hydrocarbon ring or a six-membered unsaturated heterocycle containing one nitrogen atom as the heteroatom, each of which may be substituted, Ring C represents a five-membered heterocycle containing one or two nitrogen atoms which may be substituted, W represents a single bond or a group represented by formula -CH=CH-, X represents a group represented by formula -N(R1)- or oxygen, Y represents carbon or nitrogen, Z represents a group represented by formula -N(R2)- or nitrogen, and R1 and R2 may be the same or different from each other and each represent hydrogen or lower alkyl; except for (1) the case wherein A is 4-methyl-benzene, W is a single bond, X is a group represented by formula -NH-, B is methoxybenzene and C is unsubstituted imidazole, (2) the case wherein A is 4-(acetamido)benzene or 4-aminobenzene, W is a single bond, X is a group represented by formula -NH-, B is unsubstituted benzene and C is unsubstituted pyrazole, and (3) the case wherein A is a benzene ring substituted by lower alkyl, nitro or halogen and X is oxygen. The composition can be used in the manufacture of a medicament for treating or preventing cancer.
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