发明名称 |
Manipulation of negative stranded RNA viruses by rearrangement of their genes and uses thereof |
摘要 |
The present invention provides a method of increasing expression of a promoter distal gene in a virus of the order Mononegavirales, and a recombinant virus constructed by such method. Also provided is a method of attenuating a virus of the order Mononegavirales, and of constructing an attenuated virus useful for a vaccine.
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申请公布号 |
US2004235135(A1) |
申请公布日期 |
2004.11.25 |
申请号 |
US20040872706 |
申请日期 |
2004.06.21 |
申请人 |
RESEARCH DEVELOPMENT FOUNDATION |
发明人 |
WERTZ GAIL W.;BALL ANDREW L. |
分类号 |
C12N15/09;A61K35/76;A61K39/00;A61K39/12;A61K39/155;A61K39/205;A61P37/02;C07K14/08;C12N7/00;C12N7/01;C12N7/04;C12N15/40;C12N15/86;(IPC1-7):C12N7/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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