发明名称 |
Process for purifying pravastin sodium from a fermentation broth |
摘要 |
<p>A process for purifying pravastatin sodium comprising the steps of: a. clarifying a fermentation broth containing pravastatin sodium to obtain a clear solution; and adjusting the clear solution to be basic having pH value ranging from pH 10 SIMILAR 13; b. adsorbing the pravastatin sodium with non-ionic resin; eluting the pravastatin sodium by water-soluble organic solvent; and forming a concentrate of pravastatin sodium; c. treating the concentrate with water-soluble anti-solvent or inorganic salt to form a precipitate of pravastatin sodium; and d. recrystallizing the precipitate for making pravastatin sodium crystal with high purity and high yield.</p> |
申请公布号 |
EP1477471(A1) |
申请公布日期 |
2004.11.17 |
申请号 |
EP20040252782 |
申请日期 |
2004.05.13 |
申请人 |
CHUNGHWA CHEMICAL SYNTHESIS & BIOTECH CO., LTD. |
发明人 |
MAI, JING-CHEN;LAIH, CHIOU-JOUR;CHIANG, YU-CHIN |
分类号 |
C07C67/56;C12P7/62;C12P17/06;(IPC1-7):C07C69/013;C12P7/42 |
主分类号 |
C07C67/56 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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