发明名称 Active hedgehog protein conjugate
摘要 A hedgehog conjugate which is characterized in that it contains: a) a polypeptide composed of 10 to 30 hydrophobic amino acids and/or amino acids which form transmembrane helices and are positively charged, b) 1 to 4 aliphatic, saturated or unsaturated hydrocarbon residues with a chain length of 10 to 24 C atoms and with a hydrophobic action or c) a hydrophobic thio compound covalently bound to a hedgehog protein and which has a several-fold increased activity and is suitable as a pharmaceutical agent.
申请公布号 US6818623(B2) 申请公布日期 2004.11.16
申请号 US20020278060 申请日期 2002.10.21
申请人 CURIS, INC. 发明人 ESSWEIN ANGELIKA;LANG KURT;RUEGER PETRA;SEYTTER TILMAN
分类号 C12N15/09;A61K38/00;A61P19/00;A61P21/00;A61P25/00;C07K14/435;C07K14/47;(IPC1-7):A61K38/17;C07K1/113 主分类号 C12N15/09
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