发明名称 |
PELLET FORMULATIONS OF ACID-LABILE ANTIULCER BENZIMIDAZOLE COMPOUNDS |
摘要 |
They comprise inert granules of sugar/starch which are: initially coated with a non-alkaline active layer having the benzimidazole compound (omeprazole, lansoprazole, pantoprazole, rabeprazole, etc.), sodium and/potassium salts of acids of formula R-O-SO3H wherein R is an alkyl radical of a (C6-C20)-fatty acid (preferably sodium lauryl sulfate), (C6-C20)-fatty acids (preferably oleic acid), sodium and/or potassium salts Of (C6-C20)-fatty acids (preferably potassium oleate), sodium carboxymethyl starch and polyvinylpyrrolidone; secondly coated with a non-alkaline barrier layer having hydroxypropylmethylcellulose; and finally coated with an enteric layer. The preferred molar ratio (sodium lauryl sulfate):(oleic acid + potassium oleate) is between 4:1 and 6:1. All coatings are done with aqueous solutions, suspensions or dispersions at a relatively high temperature, and all dryings are done at a relatively low temperature and for a relatively short time. They are stable over time and useful for oral administration. |
申请公布号 |
WO2004096218(A2) |
申请公布日期 |
2004.11.11 |
申请号 |
WO2004EP50618 |
申请日期 |
2004.04.27 |
申请人 |
LABORATORIOS BELMAC, S.A.;CARVAJAL MARTIN, LUIS;ASENSIO ASENSIO, JUAN CARLOS;SEVILLA TIRADO, FRANCISCO JAVIER |
发明人 |
CARVAJAL MARTIN, LUIS;ASENSIO ASENSIO, JUAN CARLOS;SEVILLA TIRADO, FRANCISCO JAVIER |
分类号 |
A61K9/50;A61K31/4439;A61P1/04 |
主分类号 |
A61K9/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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