| 摘要 |
FIELD: medicine, pharmacy. ^ SUBSTANCE: invention relates to polypeptide-base sustained-release pharmaceutical compositions, namely, water-insoluble salt of pharmaceutically active ionic peptide and counter ionic macromolecule-carrier. Peptide can represent a LHRH antagonist (luteinizing hormone-releasing hormone), such as cetrorelix, and macromolecule can represents anionic polysaccharide, such as carboxymethylcellulose. Salt is prepared using ion-exchange resins for separate removing counterions from peptide and macromolecule-carrier forms free ions of peptide/macromolecule. Then these free ions of peptide and macromolecules are mixed to form water-insoluble peptide-macromolecule salt. Invention provides expanding assortment of pharmaceutical agents of protein nature with sustained-release effect. ^ EFFECT: improved preparing method, valuable properties of composition. ^ 55 cl, 2 tbl, 2 dwg, 7 ex |
