| 发明名称 |
CYCLIC QUATERNARY AMINO DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS |
| 摘要 |
<p>Compounds of formula (1) wherein,m,n,R<1>,R<2>,R<a>,ALK<3>, E and Y are as defined in the claims, being potent and selective inhibitors of chemokine binding to the CXCR3 receptor, are accordingly of use in the treatment and/or prevention of conditions involving inappropriate T-cell trafficking, including inflammatory, autoimmune and immurforegulatory disorders such as rheumatoid arthritis.</p> |
| 申请公布号 |
WO2004094381(A1) |
申请公布日期 |
2004.11.04 |
| 申请号 |
WO2004GB01559 |
申请日期 |
2004.04.08 |
| 申请人 |
CELLTECH R & D LIMITED;WATSON, ROBERT, JOHN;MEISSNER, JOHANNES, WILHELM, GEORG;OWEN, DAVID, ALAN |
发明人 |
WATSON, ROBERT, JOHN;MEISSNER, JOHANNES, WILHELM, GEORG;OWEN, DAVID, ALAN |
| 分类号 |
C07D409/12;A61P37/02;A61P37/08;C07D211/58;(IPC1-7):C07D211/58;A61K31/452 |
主分类号 |
C07D409/12 |
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