The invention provides methods for producing mixtures of antibodies from a single host cell clone. Thereto a nucleic acid sequence encoding a light chain, and nucleic acid sequences encoding different heavy chains are expressed in a recombinant host cell. The antibodies in the mixtures according to the invention suitably comprise identical light chains paired to different heavy chains capable of pairing to the light chain, thereby forming functional antigen binding domains. Mixtures of antibodies are also provided by the invention. Such mixtures can be used in a variety of fields.
申请公布号
WO2004009618(A3)
申请公布日期
2004.11.04
申请号
WO2003EP07690
申请日期
2003.07.15
申请人
CRUCELL HOLLAND B.V.;VAN BERKEL, PATRICK, HENDRIKUS, CORNELIS;BRUS, RONALD, HENDRIK, PETER;BOUT, ABRAHAM;LOGTENBERG, TON
发明人
VAN BERKEL, PATRICK, HENDRIKUS, CORNELIS;BRUS, RONALD, HENDRIK, PETER;BOUT, ABRAHAM;LOGTENBERG, TON