摘要 |
A method for identifying an anti-streptococcal agent, comprises: (a) providing, as a first component, an isolated streptococcal M protein or a functional variant thereof; (b) providing, as a second component, isolated fibrinogen or a functional variant thereof; (b) providing, as a third component, an isolated beta2 integrin or a functional variant thereof; (d) contacting said components with a test substance under conditions that would permit the components to interact in the absence of the test substance; and (e) determining whether the test substance inhibits the interaction between the components; thereby to determine whether a test substance is an anti-streptococcal agent. |
申请人 |
HANSA MEDICAL RESEARCH AB;BJOERCK, LARS;HERWALD, HEIKO;MOERGELIN, MATTHIAS;RUSSELL, WAYNE;NORRBY-TEGLUND, ANNA;LINDBOM, LENNART;SOLLENBERG, ULLA;CRAMER, HENNING;FLODGAARD, HANS |
发明人 |
BJOERCK, LARS;HERWALD, HEIKO;MOERGELIN, MATTHIAS;RUSSELL, WAYNE;NORRBY-TEGLUND, ANNA;LINDBOM, LENNART;SOLLENBERG, ULLA;CRAMER, HENNING;FLODGAARD, HANS |