METHOD FOR MASS SPECTROMETRY INVOLVING FLUORESCENT LABELING OF THE ANALYTE

摘要

This invention relates to mass spectrometric identification of biomolecules that occur in very small amounts in the tissues or cells or living body. Specifically, the invention provides a method for promoting the ionization of those biomolecules which have heretofore been held difficult to ionize, especially sugar chains. The method according to the invention of performing mass spectrometry on biomolecules comprises marking a biomolecule with a fluorescence labeling agent that has a reactive group capable of binding to the biomolecule and a positive total charge of from +1 to +6 or a negative total charge of from -6 to -1.