Verfahren zur Herstellung von 2-[2-(5-Nitrofuryl)-vinyl]-azolderivaten

摘要

The invention comprises nitrofuran derivatives of the formula in which X is a sulphur or oxygen atom, or an imino group which may be substituted with an acetyl or propionyl group or an alkyl group of 1 to 3 carbon atoms, each of R1 and R2, is a hydrogen atom or an alkyl group of 1 to 3 carbon atoms, or R1 and R2 when taken together form a butadienylene radical which forms an extended aromatic structure with the azole ring to which it is attached. The compounds are prepared by condensing an appropriate 2-methylazole and 5-nitrofurfural, e.g. at 50 DEG to 150 DEG C., in the presence of a condensing agent and preferably in an inert solvent. The 1-acyl-2-[2-(5-nitro-2-furyl)-vinyl] -imidazoles may also be prepared by (a) condensing a 2-methyl-imidazole and 5-nitrofurfural in the presence of acetic or propionic anhydride or (b) acylating a 2-[2-(5-nitro-2-furyl)-vinyl] -imidazole with an appropriate acylating agent. The compounds have anti-bacterial activity. Reference has been directed by the Comptroller to Specification 966,832.