发明名称 |
METHODS OF TREATING PATIENTS SUFFERING FROM MOVEMENT DISORDERS |
摘要 |
<p>The present invention is directed to methods of treating movement disorders by administering an effective amount of one or more adenosine A 2A receptor antagonists to a patient in need thereof. The present invention also provides methods of decreasing the adverse effects of L-DOPA in patients receiving L-DOPA therapy in the treatment of Parkinson's disease. The present invention further provides methods and compositions for treating Parkinson's disease patients with sub-clinically effective doses of L-DOPA by combining L-DOPA treatment with an effective amount of one or more adenosine A 2A receptor antagonists (i.e., L-DOPA sparing effect). The present invention further provides methods of effective treatment of Parkinson's disease by co-administering at least one adenosine A 2A receptor antagonist, L-DOPA and a dopamine agonist and/or a COMT inhibitor and/or a MAO inhibitor. The present invention further provides methods of prolonging effective treatment of Parkinson's disease by administering an adenosine A 2A receptor antagonist singly or together with a dopamine agonist, and/or a COMT inhibitor, and/or a MAO inhibitor without prior or subsequent administration of L-DOPA, delaying or removing on-set of L-DOPA motor complication.</p> |
申请公布号 |
EP1469855(A2) |
申请公布日期 |
2004.10.27 |
申请号 |
EP20030705971 |
申请日期 |
2003.01.28 |
申请人 |
KYOWA HAKKO KOGYO CO., LTD. |
发明人 |
KASE , HIROSHI;MORI ,AKIHISA;WAKI ,YUTAKA;OHSAWA ,YUTAKA;KARASAWA ,AKIRA;KUWANA ,YOSHIHISA |
分类号 |
C07D473/06;A61K31/522;A61K45/00;A61P25/14;A61P25/16;(IPC1-7):A61K31/522 |
主分类号 |
C07D473/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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