| 摘要 |
A porous synthetic membrane suitable for conducting macromolecular fluid separations (e.g., protein filtration) is described. The ultraporous membrane comprises a surface-charge layer of crosslinked polymer, the crosslinked polymer being formed from a cellulosic polymer and a crosslinking reagent. The cellulosic polymer has substantial crosslinkable hydroxyl moiety content. The crosslinking reagent is a bi- or multi-functional epoxide capable of reacting with and binding to the cellulosic polymer's hydroxyl moieties and has the formula X(CH2)nY, wherein: n is an integer from 1 to 5; X is H2COCH or H2COCHCH2O; and Y is a halogen, H2COCH, or H2COCHCH2O. The porous synthetic membrane has good durability and good protein binding characteristics. Surface charge is provided by covalently binding a charged moiety onto a surface of said layer of crosslinked polymer.
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