摘要 |
This invention features a compound of formula (I): R1 is aryl or heteroaryl; each of R2 and R4, independently, is H, halogen, CN, alkyl, OR<a>, or NR<a>R<b>; R3 is H, halogen, CN, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cyclyl, heterocyclyl, OR<a>, OC(O)R<a>, OC(O)NR<a>R<b>, NR<a>R<b>, NR<a>C(O)R<b>, NR<a>S(O)R<b>, NR<a>S(O)2R<b>, NR<a>C(O)NR<b>R<c>, NR<a>C(S)NR<b>R<c>, NR<a>C(NR<b>)NR<c>R<d>, NR<a>C(O)OR<b>, S(O)NR<a>R<b>, S(O)2NR<a>R<b>, S(O)R<a>, S(O)2R<a>, C(O)R<a>, C(O)OR<a>, or C(O)NR<a>R<b>; R5 is H or alkyl; n is 0, 1, 2, 3, 4, 5, or 6; A is 0, S, S(O), S(O)2, or NR<e>; B is N or CR<f>; X is O, S, S(O), S(O)2, NR<c>, or C(O); Y is a covalent bond, C(O), C=NR<a >O, S, S(O), S(O)2, or NR<e>; Z is N or CH; each of U and V, independently, is N or CR; and W is O, S, or NR<e>; in which each of R<a>, R<b>, R<c>, and R<d>, independently, is H, alkyl, aryl, heteroaryl, cyclyl, or heterocyclyl; R<e >is H, alkyl, aryl, acyl, or sufonyl; and R<f >is H, alkyl, aryl, acyl, sulfonyl, alkoxyl, amino, ester, amide, CN, or halogen. The compound is useful for treating an interleukin-12 overproduction-related disorder.
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