发明名称 |
Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof |
摘要 |
An infectious clone based on the genome of a wild-type RNA virus is produced by the process of providing a host cell not susceptible to infection by the wild-type RNA virus, providing a recombinant nucleic acid based on the genome of the wild-type RNA virus, transfecting the host cell with the recombinant nucleic acid and selecting for infectious clones. The recombinant nucleic acid comprises at least one full-length DNA copy or in vitro-transcribed RNA copy or a derivative of either. The infectious clones can be used in single or dual purpose vaccines and in viral vector vaccines. |
申请公布号 |
US2004197872(A1) |
申请公布日期 |
2004.10.07 |
申请号 |
US20030750410 |
申请日期 |
2003.12.30 |
申请人 |
MEULENBERG JOHANNA JACOBA MARIA;POL JOHANNES MARIA ANTONIUS;BOS-DE RUIJTER JUDY NORMA ALETTA |
发明人 |
MEULENBERG JOHANNA JACOBA MARIA;POL JOHANNES MARIA ANTONIUS;BOS-DE RUIJTER JUDY NORMA ALETTA |
分类号 |
G01N33/569;A61K39/00;A61K39/12;A61P37/04;C07K14/08;C12N5/00;C12N5/10;C12N15/09;C12N15/40;C12Q1/68;(IPC1-7):C07H21/04;C12N7/00;C12N15/867 |
主分类号 |
G01N33/569 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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