| 发明名称 |
IN VIVO METHOD FOR DETECTING DOPAMINE D3 RECEPTORS LIGANDS. |
| 摘要 |
<p>The invention provides a method in vivo detecting anti-D3 receptor activity of dopamine D3 receptor ligands. The method of the invention makes use of a NMDA glutamate receptor antagonist to induce D3-mediated behavioral abnormalities and assess reversing effects of candidate ligands. The invention further relates to the use of a dopamine D3 receptor partial agonist or antagonist for the treatment of a substance-induced psychotic disorder or a dyskinesia associated with associated with dopamine agonist therapy.</p> |
| 申请公布号 |
WO2004084952(A1) |
申请公布日期 |
2004.10.07 |
| 申请号 |
WO2004IB00815 |
申请日期 |
2004.03.19 |
| 申请人 |
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM);SOKOLOFF, PIERRE;LERICHE, LUDOVIC |
发明人 |
SOKOLOFF, PIERRE;LERICHE, LUDOVIC |
| 分类号 |
A61K31/495;A61K31/496;A61K49/00;(IPC1-7):A61K49/00 |
主分类号 |
A61K31/495 |
| 代理机构 |
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