TRANSFORMED PLANT CELL EXPRESSING TANDEM REPEATS OF BETA-AMYLOID GENE AND RECOMBINANT PLANT PRODUCED BY TISSUE-CULTIVATION OF THE SAME

摘要

PURPOSE: A transformed plant cell expressing tandem repeats of beta-amyloid gene and a recombinant plant produced by tissue-cultivation of the transformed cell are provided. The plant expressing tandem repeats of beta-amyloid gene can be useful for development of oral vaccine for prevention and treatment of dementia. CONSTITUTION: The transformed plant cell expresses tandem repeats of beta-amyloid gene, wherein the plant is a potato or a tomato; and the tandem repeats of beta-amyloid gene consist of 3 or 5 genes. A method for producing the recombinant plant which contains the tandem repeats of beta-amyloid gene comprises the steps of: transforming Agrobacterium tumefaciens with a vector containing the tandem repeats of beta-amyloid gene to produce Agrobacterium tumefaciens LB4404(KCTC 10444BP); co-culturing the Agrobacterium tumefaciens LB4404(KCTC 10444BP) with plant cell to produce a transformed plant cell expressing tandem repeats of beta-amyloid gene; regenerating the transformed plant cell to produce its callus; and inducing a recombinant plant from the callus of the transformed plant cell.