Aminopyridinyl-, aminoguanidinyl- and alkoxyguanidinyl- substituted phenyl acetamides as protease inhibitors

摘要

Disclosed are compounds of formula I, wherein: Y is -NH- or -O-, W is H, R1, R1OC(O), R1C(O), R1(CH2)sNHC(O), R1S(O)2, or (R1)2CH(CH2)NHC(O), B is a group selected from formula II or III, and the remaining substituents are defined herein. The compounds are used in the manufacture of medicaments for use as protease and thrombin inhibitors to treat diseases such as proteolysis, thrombosis, ischemia, stroke, restenosis or inflammation.