Water-insoluble drugs co-ground with a cross-linked polymeric carrier in dry conditions so they are more soluble and bioavailable

摘要

Described is a process for preparing a highly activated composite of one or more water-insoluble drugs, the process comprising the steps of: (a) subjecting a water-insoluble drug and a cross-linked polymer to co-grinding; (b) exposing the ground product of step (a) to contact with water or water vapours. The resulting composite contains large amounts of drug in the easily soluble amorphous form, reduced amounts of drug in the nanocrystalline form, and is substantially free from insoluble drug crystals.