发明名称 |
Retrovirus vectors derived from avian sarcoma leukosis viruses permitting transfer of genes into mammalian cells and therapeutic uses thereof |
摘要 |
Recombinant avian sarcoma leukosis virus (ASLV)-derived retrovirus vectors having an expanded host range are described. The host range is expanded by the replacement of the ASLV envelope gene by an envelope gene from a virus capable of infecting both mammalian and avian cells. The resulting recombinant ASLV-derived retroviral vectors can replicate efficiently in avian cells, infect both avian and mammalian cells in high titer, and are replication-defective in mammalian cells. Thus, they are quite safe and advantageous for use in gene therapy and vaccines.
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申请公布号 |
US6794188(B2) |
申请公布日期 |
2004.09.21 |
申请号 |
US20010961933 |
申请日期 |
2001.09.24 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
BARSOV EUGENE;HUGHES STEPHEN H. |
分类号 |
A61K48/00;C07K14/15;C12N7/01;C12N15/867;(IPC1-7):C12N15/86;C12N15/87;C12N15/63;C12N5/00 |
主分类号 |
A61K48/00 |
代理机构 |
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地址 |
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