发明名称 METHOD FOR PRESERVING SMALL DOSES OF ANTIGEN IN LIQUID NITROGEN
摘要 FIELD: microbiology, medicine. ^ SUBSTANCE: invention relates, in particular, to methods for preserving diagnostic preparations. Antigen drops of size 35-40 mm3 are dropped by Pasteur's pipette or syringe (volume is 2-3 ml) with needle on liquid nitrogen surface. In the process of freezing antigen drops form "globules" that fell on tube bottom. Freezing temperature under these conditions is (-170)-(-180)oC and time for formation of "globules" is 1 min. Then "globules" are transferred into plastic bottles in common with nitrogen for storing. Method provides retention of activity and specificity of antigen for a prolonged time. ^ EFFECT: improved preserving method. ^ 4 tbl, 3 ex
申请公布号 RU2236452(C2) 申请公布日期 2004.09.20
申请号 RU20020121543 申请日期 2002.08.05
申请人 发明人 TRUKHACHEV V.I.;POZOV S.A.;ORLOVA N.E.
分类号 C12N1/04;A61K39/00;G01N25/14 主分类号 C12N1/04
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