TETRAZOLE AND OXADIAZOLONE SUBSTITUTED .BETA.-AMINO ACID DERIVATIVES

摘要

This invention relates to novel tetrazole and oxadiazalone .beta.-amino acid s derivatives of the formula (I, II), wherein G is (III, IV) wherein R1 throug h R4 are defined as in the specification, pharmaceutical compositions containi ng them and their use for the treatment of various central nervous system and other disorders. The cyclopropyl .beta.-amino acids derivatives of this invention exhibit activity as alpha2delta ligands (.alpha.2.delta. ligands). Such compounds have affinity for the .alpha.2.delta. subunit of a calcium channel.