发明名称 |
Mutants of monoamine oxidase B |
摘要 |
A highly conserved active site helix present within the P-450 superfamily of proteins is found also in monoamine oxidase (MAO) B, a major enzyme that catalyzes deamination of neuro- and vaso-active amines in the nervous system of mammals. Mutation within the conserved region of the MAO B enzyme directly reduces MAO B's activity and alters its pH profile, which allows for indirect regulation of the cellular neurotransmitters and vasoamines.
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申请公布号 |
US6790646(B2) |
申请公布日期 |
2004.09.14 |
申请号 |
US20020119604 |
申请日期 |
2002.04.10 |
申请人 |
RESEARCH DEVELOPMENT FOUNDATION |
发明人 |
ABELL CREED W.;LEWIS DUANE A. |
分类号 |
C12N9/06;C12N15/12;C12N15/53;(IPC1-7):C12N9/06 |
主分类号 |
C12N9/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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