PERFLUOROCARBON AND HYDROFLUOROCARBON FORMULATIONS AND METHODS OF MAKING AND USING SAME

摘要

A liquid aerosol generating formulation comprising medicament and at least one liquid perfluorocarbon and/or hydrofluorocarbon. The formulation can include at least one surfactant which stabilizes the medicament. An aerosol of medicament particles can be formed by heating the formulation in a flow passage such that the liquid perfluorocarbon and/or hydrofluorocarbon is vaporized and expands out of an outlet of the flow passage. The flow passage can be a heated capillary sized flow passage in a hand held inhaler. The liquid perfluorocarbon and/or hydrofluorocarbon can deliver drugs having low solubility and/or low potency to a patient as a soft mist aerosol requiring minimal patient coordination.