发明名称 |
NOVEL TRANSCRIPTIONAL FACTOR, PROCESS FOR PRODUCING THE SAME AND USE THEREOF |
摘要 |
<p>A novel imino compound is synthesized by mixing and reacting ascochlorin, its analog or its derivative with a compound having a primary amino group in the presence/absence of a basic catalyst. The novel imino compound thus synthesized is a ligand which activates nuclear receptor superfamily such as retinoid orphan receptor (RXR), peroxiosme proliferator activated receptor (PPAR) and steroid receptor (PXR) and shows an effect of promoting the transcription of a drug-metabolizing enzyme CYP7A1. It has therapeutic effects on diseases such as life style-related diseases, chronic inflammation and cancer.</p> |
申请公布号 |
WO2004074236(A1) |
申请公布日期 |
2004.09.02 |
申请号 |
WO2004JP02110 |
申请日期 |
2004.02.24 |
申请人 |
NRL PHARMA INC;KITAHARA TAKESHI;WATANABE HIDENORI;ANDO KUNIO |
发明人 |
KITAHARA TAKESHI;WATANABE HIDENORI;ANDO KUNIO |
分类号 |
A61P3/06;A61K31/198;A61K31/223;A61K31/341;A61P3/10;A61P9/10;A61P9/12;A61P29/00;A61P35/00;C07C249/02;C07C251/24;C07C403/18;C07D307/32;(IPC1-7):C07C249/02 |
主分类号 |
A61P3/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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