发明名称 |
TRANSDERMAL PENETRATION ENHANCERS |
摘要 |
<p>The invention provides compounds based on ceramide analogues of the general the general formula (I), wherein R1= H or CH2OH; R2 = C8 to C16 alkyl; R3 = C7 to C15 alkyl, cis-heptadec-8-en-1-yl, CH(R1)NHCOR4, CH=CHCOOR4 or CH(OH)CH(OH)COOR4; R4 = C7 to C16 alkyl. The compounds of the general formula (I) are used as transdermal penetration enhancers. Pharmaceutical and cosmetic compositions, containing ceramide analogues of the general formula (I) in the amount from 0.1 to 5.0 w/w percent, preferably in the amount from 0.1 to 1.0 w/w percent.</p> |
申请公布号 |
WO2004074235(A1) |
申请公布日期 |
2004.09.02 |
申请号 |
WO2004CZ00010 |
申请日期 |
2004.02.23 |
申请人 |
UNIVERZITA KARLOVA V PRAZE;VAVROVA, KATERINA;HRABALEK, ALEXANDR;DOLEZAL, PAVEL;HOLAS, TOMAS |
发明人 |
VAVROVA, KATERINA;HRABALEK, ALEXANDR;DOLEZAL, PAVEL;HOLAS, TOMAS |
分类号 |
C07C237/12;A61K31/16;A61K38/00;C07C233/47;C07C233/49;C07C235/12;C07K5/06;(IPC1-7):C07C233/47;C07K5/062;A61K47/18;A61K7/48 |
主分类号 |
C07C237/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|