发明名称 |
Selective modulation of TLR-mediated biological activity |
摘要 |
Methods of identifying a compound that selectively modulates at least one TLR-mediated cellular activity are disclosed. Generally, the methods include identifying a compound as a compound that selectively modulates at least one TLR-mediated cellular activity if the compound modulates one TLR-mediated cellular activity to a different extent than it modulates a second TLR-mediated cellular activity. Compounds so identified and pharmaceutical compositions including such compounds are also disclosed. Methods of selectively modulating immune cells and methods of treating certain conditions are also provided. Such methods include administering to cells or a subject a compound that selectively modulates a TLR-mediated cellular activity.
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申请公布号 |
US2004171086(A1) |
申请公布日期 |
2004.09.02 |
申请号 |
US20040788731 |
申请日期 |
2004.02.27 |
申请人 |
3M INNOVATIVE PROPERTIES COMPANY |
发明人 |
FINK JASON R.;GORDEN KEITH B.;GORSKI KEVIN S.;GUPTA SHALLEY K.;QIU XIAOHONG;VASILAKOS JOHN P. |
分类号 |
A61K31/00;A61K31/44;G01N33/566;(IPC1-7):G01N33/53;G01N33/567 |
主分类号 |
A61K31/00 |
代理机构 |
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