| 摘要 |
The present invention provides an amide derivative represented by the following formula Ä1Ü: <CHEM> wherein n represents 0 or 1; X represents CR<4> or N; Y represents CR<6> or N; Z represents CR<7> or N; R<1> and R<2> may be the same or different and each represents hydrogen, optionally substituted alkyl, acyl, optionally substituted aryl, or an optionally substituted aromatic heterocyclic group; R<4>, R<5>, R<6> and R<7> may be the same or different and each represents hydrogen, halogen, hydroxy, amino, alkyl, haloalkyl, alkoxy, monoalkylamino, dialkylamino, arylalkyl, cyano, or nitro; and R<3> represents optionally substituted alkylamino, optionally substituted arylamino, or optionally substituted cyclic amino, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising them as an active ingredient. <??>The compound of the present invention is useful as a TGF- beta inhibitor.
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