INHIBITORS OF METALLOPROTEINASE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, THEIR PHARMACEUTICAL APPLICATION AND METHODS AND INTERMEDIATE COMPOUNDS FOR THEIR PREPARATION

摘要

The invention relates to compounds with the formula where Z is O or S, V is bivalent radical which together with C* and N forms a ring containing 6 ring atoms, each of these atoms being different from C* and N, independently from each other in unsubstituted or substituted by a suitable substituent and at least one of these other ring atoms is heteroatom selected from O, N & S, and the remaining being carbon atoms, Ar is aryl or heteroaryl group. The invention also relates to pharmaceutically acceptable promedicamentous forms, salts and solvates of these compounds, as well as to the method for the inhibition of the activity of the metalloproteinases by the application of the above compounds or their promedicamentous forms or salts, or solvates. The invention also relates to pharmaceutical compositions containing an effective quantity of the compounds, the promedicamentous forms, their salts or solvates, as well as to the methods and the intermediate compounds for their preparation.