发明名称 |
PHARMACEUTICALS FORMULATIONS AND METHODS FOR MODIFIED RELEASE OF STATIN DRUGS |
摘要 |
The present invention is directed to compositions and methods of their use in treating, preventing, and/or managing one or more cardiovascular diseases using at least one poorly water-soluble statin, such as, for example, simvastatin and/or lovastatin. One method of the invention involves delaying release of the poorly water-soluble statin for a time sufficient to avoid metabolism of the statin at or near the gastrointestinal tract wall by the cytochrome P450 3A metabolic system, and releasing said statin in the ileum, colon, or both, with subsequent uptake into the hepatic portal vein and distribution to hepatocytes, wherein HMG-CoA reductase activity may be inhibited with minimal adverse drug interactions. |
申请公布号 |
WO2004021972(A3) |
申请公布日期 |
2004.08.12 |
申请号 |
WO2003IB04361 |
申请日期 |
2003.09.03 |
申请人 |
BIOVAIL LABORATORIES, INC.;BUTLER, JACKIE;DEVANE, JOHN;STARK, PAUL |
发明人 |
BUTLER, JACKIE;DEVANE, JOHN;STARK, PAUL |
分类号 |
A61K9/20;A61K9/28;A61K31/225;A61K31/35;A61K31/366;A61K31/401;A61K45/06 |
主分类号 |
A61K9/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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