PIPERAZINE DERIVATIVES FOR USE AS CCR-3 RECEPTOR ANTAGONISTS IN THE TREATMENT OF ASTHMA.

摘要

The present invention relates to piperazine derivatives of Formula (I), wherein: R1-R4, A, L, and X are as defined in the specification. The compounds are useful as CCR-3 receptor antagonists, and therefore, may be used for the treatment of CCR-3 mediated diseases such as asthma.